DES(1-3) IGF-1, 1 mg. DES(1-3) IGF-1 is a truncated form of insulin-like growth factor 1, missing the first three amino acids, which lowers its affinity for binding proteins.
DES(1-3) IGF-1 1 mg by Genheal
50 EUR190,00 złAdd to cartAvailable on backorder
What is in this vial
Both brands of DES(1-3) IGF-1 here come in the same 1 mg vial, so the choice between them is a choice of manufacturer and price, not of quantity. The powder has no concentration of its own: it is set when you add the water. This vial with 1 ml of bacteriostatic water gives 1 mg per millilitre, and with twice that volume, half as much.
The conversion of an amount into insulin syringe units is worked through in the guide on syringe units, and the rules that change once the powder is dissolved are in storage.
Genheal as the manufacturer
Genheal covers the growth hormone axis more completely than the other two brands and is the only one here supplying the BPC-157 and TB-500 blend and tesamorelin. Its vials carry a code under the hologram and a batch certificate, checked the same way as any other brand in this shop.
What the evidence says
There are no published human trials of this molecule for muscle applications and no established human dose. What is known comes from animal and cell work. The full account, with the sources and the limits, is on the DES(1-3) IGF-1 page, and the background in the guide on IGF-1 LR3 and DES(1-3) IGF-1.
We publish no dosing schedules. Sold as research material, not as a medicine.
Genheal fills DES(1-3) IGF-1 in the same 1 mg vial as Bio-Peptide. The three missing amino acids at the start of the chain are the whole modification, and they are what lets the molecule escape the binding proteins that hold natural IGF-1 inactive.
Concentration in this vial
| Water added | Concentration | Per unit on a U-100 syringe |
|---|---|---|
| 1 ml | 1 mg/ml | 10 mcg |
| 2 ml | 0.5 mg/ml | 5 mcg |
| 5 ml | 0.2 mg/ml | 2 mcg |
The table is arithmetic and nothing else: it converts the 1 mg in this vial into the concentration you get for a chosen volume of bacteriostatic water. It is not a dosing recommendation, and we publish none.
This vial next to the other DES(1-3) IGF-1 vials
The same compound is sold here in one other version: Bio-Peptide, 1 mg. The molecule is identical in each; what differs is the manufacturer. Both hold the same amount, so the choice here is the manufacturer and its batch certificate, not the size.
Also from Genheal in this group
Within Muscle peptides, Genheal also supplies ACE-031 10 mg, Follistatin 344 1 mg and IGF-1 LR3 1 mg.
What the name says
The prefix des in chemical naming means that something is missing, and the numbers in brackets show which amino acid residues are absent. DES(1-3) IGF-1 is therefore the IGF-1 molecule without the first three amino acids of its chain; the rest stays unchanged. The whole point of such modifications in this family is to change how the molecule binds to the carrier proteins circulating in the blood: natural IGF-1 is captured by them, and the modified variants are meant to be captured less.
What we can say honestly: comparisons of potency between IGF-1 variants, easy to find in sales copy, come from cell culture tests, not from clinical trials.
What this group of molecules targets
Once bound to its receptor, IGF-1 switches on the PI3K, Akt and mTOR pathway. It increases muscle protein synthesis, slows protein breakdown by blocking FOXO proteins and stimulates satellite cells. That describes how the natural growth factor works in the body, not the result of giving its analogue from outside, and the difference runs through this whole product group.
Two variants in our range
| Feature | DES(1-3) IGF-1 | IGF-1 LR3 |
|---|---|---|
| What was changed | The first three amino acids of the chain removed | A change that limits binding to carrier proteins |
| Vial content | 1 mg | 1 mg |
| Syringe unit after dissolving in 1 ml | 10 mcg | 10 mcg |
Two risks are listed for molecules aimed at the IGF-1 axis: hypoglycaemia, a drop in blood sugar, and suppression of the body's own growth hormone and IGF-1 axis through feedback in the hypothalamus and pituitary, described in animals. None of the molecules in this group is approved for building muscle or improving sports performance.
What the original studies of DES(1-3) IGF-1 showed
DES(1-3) IGF-1 is IGF-1 without its first three amino acids: glycine, proline and glutamic acid. It occurs naturally. It was described in bovine colostrum and later in brain tissue. The most important data on it were gathered by the team of Ballard and Francis, co-authors of the later paper on IGF-1 LR3.
| Study | What was tested | Result |
|---|---|---|
| Ballard et al., 1987 | protein synthesis in L6 muscle cells | about 7 times stronger than IGF-1 |
| Ross et al., 1989 | action in the presence of IGF binding proteins | the binding proteins blocked IGF-1 and IGF-2, but not DES(1-3) IGF-1 |
| Ballard et al., 1991 | clearance from the blood in rats | 4.59 ml/min/kg against 1.20 for IGF-1, almost 4 times faster |
The first row is interesting for one reason. The greater strength of DES(1-3) IGF-1 did not come from binding the IGF-1 receptor more strongly. It came from the fact that the binding proteins around the cells hardly hold it back, so more free peptide reaches the receptor.
The third row explains the short action. In the blood, DES(1-3) IGF-1 practically does not bind to the binding proteins that act as a store for ordinary IGF-1. That is why it disappears faster and spreads more widely through the tissues. Its volume of distribution was 461 ml/kg against 167 ml/kg for IGF-1.
All of this comes from cells and rats. No human studies have been published, and DES(1-3) IGF-1 is on the WADA list in group S2, banned at all times. A comparison with IGF-1 LR3 is in the guide IGF-1 LR3 and DES(1-3) IGF-1.
Sources: Ballard et al., Biochemical and Biophysical Research Communications 1987, Ross et al., Biochemical Journal 1989, Ballard et al., Journal of Endocrinology 1991.
Questions
How much DES(1-3) IGF-1 is in this vial?
1 mg of lyophilised powder from Genheal, in one vial.
What concentration does 2 ml of water give?
0.5 mg per millilitre, which is 5 mcg per unit on a U-100 insulin syringe. Other volumes are in the table above.
Is this the same molecule as the Bio-Peptide vial?
Yes. DES(1-3) IGF-1 is the same compound in every vial here, and both hold 1 mg. What differs is the manufacturer and the batch certificate that comes with it.
Verification and delivery
Every vial carries a code under the hologram and comes from a batch with a certificate of analysis; how to check both is described in check your product. We ship within Poland and abroad. Outside Poland shipping costs 30 EUR paid in advance or 80 EUR cash on delivery, the same for every country: shipping and payments.