ACE-031, 10 mg. ACE-031, also written ACVR2B, is a fusion protein working as a decoy receptor: it captures myostatin and related molecules before they reach cells.
ACE-031 (ACVR2B) 10 mg by Genheal
75 EUR300,00 złAdd to cartAvailable on backorder
What is in this vial
All three brands of ACE-031 here come in the same 10 mg vial, so the choice between them is a choice of manufacturer and price, not of quantity. The powder has no concentration of its own: it is set when you add the water. This vial with 2 ml of bacteriostatic water gives 5 mg per millilitre, and with twice that volume, half as much.
The conversion of an amount into insulin syringe units is worked through in the guide on syringe units, and the rules that change once the powder is dissolved are in storage.
Genheal as the manufacturer
Genheal covers the growth hormone axis more completely than the other two brands and is the only one here supplying the BPC-157 and TB-500 blend and tesamorelin. Its vials carry a code under the hologram and a batch certificate, checked the same way as any other brand in this shop.
What the evidence says
It is the one molecule in this group that reached clinical trials. Those trials were halted on safety grounds in 2011 and the programme closed in 2013. The full account, with the sources and the limits, is on the ACE-031 page, and the background in the guide on follistatin 344 and ACE-031.
We publish no dosing schedules. Sold as research material, not as a medicine.
Genheal lists this molecule under the name ACVR2B rather than ACE-031, which is the receptor it is built from. It is the same compound as on the other two brand pages, in the same 10 mg vial, and the name is the only thing that differs.
Concentration in this vial
| Water added | Concentration | Per unit on a U-100 syringe |
|---|---|---|
| 1 ml | 10 mg/ml | 100 mcg |
| 2 ml | 5 mg/ml | 50 mcg |
| 5 ml | 2 mg/ml | 20 mcg |
The table is arithmetic and nothing else: it converts the 10 mg in this vial into the concentration you get for a chosen volume of bacteriostatic water. It is not a dosing recommendation, and we publish none.
This vial next to the other ACE-031 vials
The same compound is sold here in two other versions: Bio-Peptide, 10 mg and Nouveaux Ltd., 10 mg. The molecule is identical in each; what differs is the manufacturer. All three hold the same amount, so the choice here is the manufacturer and its batch certificate, not the size.
Also from Genheal in this group
Within Muscle peptides, Genheal also supplies DES(1-3) IGF-1 1 mg, Follistatin 344 1 mg and IGF-1 LR3 1 mg.
What myostatin is and why block it
Myostatin, also labelled GDF-8, is a protein of the TGF-beta superfamily that restrains the growth of skeletal muscle. Animals and people with a mutation that switches off the myostatin gene have clearly more muscle mass. That observation is the basis of the whole idea of blocking this protein with a drug.
ACE-031 is a fusion protein based on the activin receptor type 2B joined to an antibody fragment. It works as a decoy receptor: it captures myostatin, activin A, activin B and related molecules before they reach muscle cells. That is where the abbreviation ACVR2B in the product name comes from.
The history of the clinical trials
ACE-031 was studied in boys with Duchenne muscular dystrophy, where blocking myostatin was meant to support muscle growth and repair. Acceleron Pharma and Shire halted those trials on 21 April 2011, and on 2 May 2013 they closed the whole programme without resuming it. The reason was safety: some participants had nose and gum bleeding and small dilated blood vessels in the skin, which resolved after stopping. They were linked to blocking BMP9 and BMP10 signals through the activin receptor, which matter for normal blood vessel function.
For a buyer this means the mechanism was tested in clinical conditions and showed both an effect on muscle and an unexpected side effect. We do not write that ACE-031 builds muscle in a proven and safe way: for healthy people there are no clinical data confirming it.
ACE-031 and follistatin 344
| Feature | ACE-031 (ACVR2B) | Follistatin 344 |
|---|---|---|
| Type of molecule | Fusion protein with the activin receptor | Protein binding TGF-beta ligands |
| How it works | Decoy receptor capturing myostatin | Binds myostatin and related ligands |
| Human studies | Programme closed in 2013 on safety grounds | No randomised trials for muscle gain |
Preparation and storage
The Genheal box holds one 1 ml solvent ampoule. Dissolved in it, the 10 mg vial gives 10 mg per millilitre, or 100 mcg per syringe unit. Wipe the rubber stopper with an alcohol swab, add the solvent slowly down the inside wall of the vial and let the powder dissolve on its own, without shaking; this is a large protein and rough handling does it no good. Keep the solution in the fridge at 2 to 8 degrees Celsius, away from light.
Who this vial is for
You want ACE-031 in the simplest set, with one ampoule: this is the vial. You want a choice of concentration: pick Bio-Peptide, which comes with two 1 ml ampoules. You would rather have nothing to prepare: the Nouveaux Ltd. cartridge has the solvent in a second chamber. You are looking for the second molecule aimed at the same pathway: that is follistatin 344.
Both fibre types: a 2010 study in mice
The first data on the effect of ACE-031 on muscle come from a mouse study published in 2010 in the Journal of Applied Physiology. Eight-week-old mice received ACE-031 or placebo for 28 days. After that time the treated mice weighed 16 percent more on average than the controls.
| Mouse muscle | Mass gain after 28 days |
|---|---|
| Gastrocnemius | 46 percent |
| Plantaris | 44 percent |
| Soleus | 33 percent |
| Extensor digitorum longus | 26 percent |
The most important result concerned the fibre type. Both types grew, slow and fast. In the soleus, the cross-section of slow fibres rose by 22 percent and of fast fibres by 28 percent. In the plantaris, fibre cross-section increased by 57 percent.
The researchers stressed that this sets ACE-031 apart from drugs that block only myostatin, which act mainly on fast fibres. Besides myostatin, ACE-031 also captures related molecules, including activins.
From mice to humans
After the animal studies, ACE-031 was tested in healthy postmenopausal women. A single injection increased whole-body lean mass by 3.3 percent and thigh muscle volume by 5.1 percent after 29 days. The half-life was 10 to 15 days. The study programme in boys with dystrophy was later closed because of nosebleeds and dilated small blood vessels. The whole story is described in the guide Follistatin 344 and ACE-031: myostatin blockers.
Sources: Cadena et al., Journal of Applied Physiology 2010, Attie et al., Muscle and Nerve 2013.
Questions
How much ACE-031 is in this vial?
10 mg of lyophilised powder from Genheal, in one vial.
What concentration does 2 ml of water give?
5 mg per millilitre, which is 50 mcg per unit on a U-100 insulin syringe. Other volumes are in the table above.
Is this the same molecule as the Bio-Peptide vial?
Yes. ACE-031 is the same compound in every vial here, and both hold 10 mg. What differs is the manufacturer and the batch certificate that comes with it.
Verification and delivery
Every vial carries a code under the hologram and comes from a batch with a certificate of analysis; how to check both is described in check your product. We ship within Poland and abroad. Outside Poland shipping costs 30 EUR paid in advance or 80 EUR cash on delivery, the same for every country: shipping and payments.