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MGF 5 mg - Bio-Peptide

MGF, 5 mg. MGF, mechano growth factor, is a 24 amino acid variant produced from the same gene as IGF-1 by alternative splicing under mechanical load.

What is in this vial

Both brands of MGF here come in the same 5 mg vial, so the choice between them is a choice of manufacturer and price, not of quantity. The powder has no concentration of its own: it is set when you add the water. This vial with 2 ml of bacteriostatic water gives 2.5 mg per millilitre, and with twice that volume, half as much.

The conversion of an amount into insulin syringe units is worked through in the guide on syringe units, and the rules that change once the powder is dissolved are in storage.

Bio-Peptide as the manufacturer

Bio-Peptide has the widest catalogue of the three brands we stock: it is the only one supplying glutathione, NAD+, GHK-Cu, MOTS-C, SLU-PP-332 and semaglutide, so an order from this manufacturer can usually be filled from one supplier. Every vial carries a code under the hologram and a batch certificate, and how to check both is described on the verification page.

What the evidence says

Its estimated half-life is measured in minutes. No completed randomised trial of administering MGF had been published as of April 2026; the human data are observational. The full account, with the sources and the limits, is on the MGF page, and the background in the guide on MGF and PEG-MGF.

We publish no dosing schedules. Sold as research material, not as a medicine.

Unmodified MGF breaks down in body fluids within minutes, and that instability is the reason the pegylated version exists. Bio-Peptide fills both, in 5 mg vials, so the pair can be compared at equal content.

Concentration in this vial

Water added Concentration Per unit on a U-100 syringe
1 ml 5 mg/ml 50 mcg
2 ml 2.5 mg/ml 25 mcg
5 ml 1 mg/ml 10 mcg

The table is arithmetic and nothing else: it converts the 5 mg in this vial into the concentration you get for a chosen volume of bacteriostatic water. It is not a dosing recommendation, and we publish none.

This vial next to the other MGF vials

The same compound is sold here in one other version: Genheal, 5 mg. The molecule is identical in each; what differs is the manufacturer. Both hold the same amount, so the choice here is the manufacturer and its batch certificate, not the size.

Also from Bio-Peptide in this group

Within Muscle peptides, Bio-Peptide also supplies ACE-031 10 mg, DES(1-3) IGF-1 1 mg and Follistatin 344 1 mg.

Where MGF comes from in the body

The IGF-1 gene does not code for a single molecule. It undergoes alternative splicing, and depending on which stretches are joined, different variants of the protein are made. One of them is the IGF-1Ec isoform, and MGF is the terminal fragment of its E-peptide, 24 amino acids long.

The signal that switches on this variant is mechanical load, hence the name mechano growth factor. MGF is therefore not a separate molecule from a separate gene, but a product of the same gene read differently; this was described, among others, in a paper published in PLOS One.

What the data show and what they do not

The human data available are observational studies measuring the body's own MGF expression after exercise, not the effect of giving the peptide from outside. In addition, one independent laboratory found no proliferative effect on primary human myoblasts, the precursor cells of muscle. That undermines some of the mechanistic claims repeated in sales copy, so we do not write that MGF acts locally on damaged fibres.

MGF and PEG-MGF

Feature MGF PEG-MGF
In the body Formed naturally from the IGF-1 gene Synthetic construct, does not occur
Structure 24 amino acids The same chain with polyethylene glycol attached
Duration of action Minutes Potentially days, depending on the size of the PEG molecule
Human studies No completed randomised trials No completed randomised trials

Two concentrations with a 5 mg vial

The Bio-Peptide box holds two solvent ampoules.

Dissolved in Concentration Syringe unit When it suits
1 ml 5000 mcg per ml 50 mcg Less liquid, simpler arithmetic
2 ml 2500 mcg per ml 25 mcg Fine scale for small portions

The vial holds 5 mg, half of a typical peptide pack, so the ratios come out lower than with 10 mg vials. Check them before the first draw rather than carrying over a habit from another product.

Preparation and storage

Wipe the rubber stopper with an alcohol swab and let it dry. Add the solvent slowly down the inside wall of the vial, not straight onto the powder. Leave the vial for a few minutes and let the contents dissolve on their own, without shaking. Keep the finished solution in the fridge at 2 to 8 degrees Celsius, away from light.

Who this vial is for

You want to work with the molecule in its unmodified form: this is the vial. You measure small portions and want a fine scale: two ampoules give 25 mcg per unit. You care about a longer duration of action: take PEG-MGF.

MGF in studies: what was tested in muscle

MGF is a form of IGF-1 that muscle makes itself after loading. In a 2003 study in The Journal of Physiology, its level in muscle rose in young men after a single strength session. In men aged 70 to 82 no such rise appeared. This is one of the observations behind the interest in giving MGF from outside.

Study Model What was found
Yang and Goldspink, 2002 myoblast culture fragment E increased cell proliferation and held back differentiation
Fornaro et al., 2014 mouse and human cells no effect on proliferation or differentiation
Liu et al., 2019 mice after muscle contusion, MGF injected into the injury less fibrosis at the injury site, without protecting fibre regeneration

The newest of these papers is closest to how the use of MGF is usually described. The mice had a muscle injured and were then injected with MGF directly into the injury. The peptide reduced fibrosis, meaning the replacement of muscle with scar tissue. It did not, however, speed up the rebuilding of the muscle fibres themselves.

So the results are mixed. Goldspink's laboratory described an effect on cells, an independent team did not confirm it, and the mouse study showed an effect on scarring, not on fibres. There are no studies giving MGF to humans. MGF is on the WADA list in group S2, banned at all times. This molecule is covered in more detail in the guide MGF and PEG-MGF.

Sources: Liu et al., Frontiers in Physiology 2019, Hameed et al., The Journal of Physiology 2003, Yang and Goldspink, FEBS Letters 2002, Fornaro et al., American Journal of Physiology 2014.

Questions

How much MGF is in this vial?

5 mg of lyophilised powder from Bio-Peptide, in one vial.

What concentration does 2 ml of water give?

2.5 mg per millilitre, which is 25 mcg per unit on a U-100 insulin syringe. Other volumes are in the table above.

Is this the same molecule as the Genheal vial?

Yes. MGF is the same compound in every vial here, and both hold 5 mg. What differs is the manufacturer and the batch certificate that comes with it.

Verification and delivery

Every vial carries a code under the hologram and comes from a batch with a certificate of analysis; how to check both is described in check your product. We ship within Poland and abroad. Outside Poland shipping costs 30 EUR paid in advance or 80 EUR cash on delivery, the same for every country: shipping and payments.