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Sermorelin, also known as GRF 1-29, is an analogue of the first 29 amino acids of growth hormone releasing hormone. Unusually for this catalogue, it was once a fully registered medicine. Sold here as research material, not as a medicine.

What is in the vial

Bio-Peptide and Genheal fill 5 mg vials, Nouveaux Ltd. fills 10 mg. A 5 mg vial with 2 ml of bacteriostatic water gives 2.5 mg per millilitre; the 10 mg vial with the same 2 ml gives 5 mg per millilitre. The arithmetic is in the guide on reconstitution.

Its registration history

Sermorelin was approved in the United States as Geref, under two separate applications: NDA 19-863, approved on 28 December 1990 at 0.05 mg per ampoule for assessing pituitary growth hormone secretion, and NDA 20-443, approved on 26 September 1997 at 0.5 mg and 1.0 mg per vial for treating idiopathic growth hormone deficiency in children with growth failure.

The manufacturer notified the FDA in 2008 that it was discontinuing both forms, and approval was withdrawn with effect from 18 June 2009. A Federal Register determination from 4 March 2013 recorded the key point: the products were not withdrawn for reasons of safety or effectiveness. The reason was commercial.

What that does and does not mean

It means this molecule once passed a full regulatory review. It does not mean the vial you buy here is Geref, has its dose, or has its quality control. That distinction holds for every molecule in this shop, and it holds here too.

Sermorelin or Mod GRF 1-29

Both are GHRH analogues and both act briefly, which is what separates them from CJC-1295 with DAC. Mod GRF 1-29 is the modified version, built to resist breakdown for longer than the unmodified fragment. Which of the two a given research question calls for is set out in the guide on sermorelin and Mod GRF 1-29.

Status

There is no registered sermorelin product today. As a GHRH analogue it falls under category S2 of the World Anti-Doping Agency list, prohibited at all times. We publish no dosing schedules; the doses quoted above describe a medicine that no longer exists on the market.

Handling and verification

Supplied as lyophilised powder. Storage rules change once it is dissolved: see storage. Check the code under the hologram as described in check your product. We ship within Poland and abroad; outside Poland the cost is quoted individually, depending on weight and destination country. Details: shipping and payments.

Questions

Was sermorelin ever an approved medicine?

Yes, in the United States as Geref, under two applications approved in 1990 and 1997. Approval was withdrawn in 2009 for commercial reasons, not for safety or effectiveness.

Can it still be prescribed?

There is no registered sermorelin product today, so the answer in the European Union and the United States is no.

How does it differ from CJC-1295 with DAC?

Duration. Sermorelin acts briefly, the DAC form holds IGF-1 elevated for days.

Is it allowed in sport?

No. GHRH analogues are prohibited at all times under category S2.