MOTS-c is a peptide of sixteen amino acids encoded in mitochondrial DNA, within the 12S rRNA gene. It belongs to the group known as mitochondrial-derived peptides and occurs naturally in humans and mice. Sold as research material, not as a medicine.
Bio-Peptide, 10 mg
170,00 złAdd to cart5 in stock (can be backordered)
What is in the vial
Bio-Peptide is the only manufacturer offering MOTS-c here, in a 10 mg vial of lyophilised powder. A 10 mg vial with 2 ml of bacteriostatic water gives 5 mg per millilitre; the arithmetic is in the guide on reconstitution and the conversion into syringe units in syringe units.
What animal studies showed
Work published in Cell Metabolism in 2015 described MOTS-c inhibiting the folate cycle and de novo purine synthesis, leading to AICAR accumulation and activation of AMPK, with skeletal muscle as the main target organ. In mice on a high-fat diet, researchers described strong AMPK activation and increased expression of the GLUT4 glucose transporter in muscle.
Reported effects in animals: faster glucose clearance, improved whole-body insulin sensitivity, and prevention of age-related and diet-induced insulin resistance and of diet-induced obesity.
What human data exist
Observational, not interventional. Circulating MOTS-c concentration correlates with markers of insulin resistance and obesity, including body mass index, waist circumference, fasting insulin, HOMA-IR and HbA1c. Clinical trials testing MOTS-c as an intervention are scarce or absent, so we do not write that it improves insulin sensitivity in people. It does so in mice.
A correlation of that kind cannot say which way the arrow points. Lower MOTS-c in people with insulin resistance is equally consistent with the peptide being a cause, a consequence or a bystander, and the studies published so far cannot separate those.
Where it sits in this catalogue
MOTS-c is listed in the skin and longevity group alongside NAD+, glutathione and GHK-Cu, which is a grouping by what buyers look for rather than by mechanism. The molecule itself is described in the guide on MOTS-c, the peptide from the mitochondrion. We publish no dosing schedules, because no interventional human study exists to take one from.
Handling and verification
Supplied as lyophilised powder. Storage rules change once it is dissolved: see storage. Check the code under the hologram and the batch certificate as described in check your product. We ship within Poland and abroad; outside Poland the cost is quoted individually, depending on weight and destination country. Details: shipping and payments.
Questions
Where does MOTS-c come from?
It is encoded in mitochondrial DNA, in the 12S rRNA gene, and occurs naturally in humans and mice.
Does it improve insulin sensitivity in people?
That has been shown in mice. In humans the data are observational correlations, which cannot establish the direction of the effect.
What does it do at the cellular level?
In the 2015 work it inhibited the folate cycle and de novo purine synthesis, leading to AICAR accumulation and AMPK activation, with skeletal muscle as the main target.
Are there clinical trials?
Interventional trials are scarce or absent, which is why this page describes animal work rather than human outcomes.