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Retatrutide, 20 mg. Retatrutide is a triple agonist acting on the GLP-1, GIP and glucagon receptors. It has completed phase 3 trials and is not approved for sale anywhere.

What is in this vial

Retatrutide comes here in two 20 mg vials, from Bio-Peptide and Genheal, and in a 40 mg ready-to-use pen from Nouveaux Ltd. Between the two vials the choice is a choice of manufacturer, not of quantity. The powder has no concentration of its own: it is set when you add the water. This vial with 2 ml of bacteriostatic water gives 10 mg per millilitre, and with twice that volume, half as much.

The conversion of an amount into insulin syringe units is worked through in the guide on syringe units, and the rules that change once the powder is dissolved are in storage.

Genheal as the manufacturer

Genheal covers the growth hormone axis more completely than the other two brands and is the only one here supplying the BPC-157 and TB-500 blend and tesamorelin. Its vials carry a code under the hologram and a batch certificate, checked the same way as any other brand in this shop.

What the evidence says

TRIUMPH-1 gave 25.0 percent weight reduction at 12 mg after 80 weeks, and 30.3 percent at 104 weeks in the subgroup with a body mass index of 35 or above. The full account, with the sources and the limits, is on the Retatrutide page, and the background in the guide on the retatrutide phase 3 programme.

We publish no dosing schedules. Sold as research material, not as a medicine.

Genheal also fills tirzepatide, so both of the newer incretin molecules can come from one producer; Bio-Peptide and Nouveaux Ltd. offer the same pairing. Retatrutide is the only one of the three sold here with no approval anywhere, and the manufacturer has announced a United States filing for the first quarter of 2027.

Concentration in this vial

Water added Concentration Per unit on a U-100 syringe
1 ml 20 mg/ml 200 mcg
2 ml 10 mg/ml 100 mcg
5 ml 4 mg/ml 40 mcg

The table is arithmetic and nothing else: it converts the 20 mg in this vial into the concentration you get for a chosen volume of bacteriostatic water. It is not a dosing recommendation, and we publish none.

This vial next to the other Retatrutide vials

The same compound is sold here in two other versions: Bio-Peptide, 20 mg, a vial of the same size, and Nouveaux Ltd., 40 mg Quick Pen, a ready solution with twice the amount and nothing to dissolve. The molecule is identical in each; between the two vials the choice is the manufacturer and its batch certificate, not the size.

Also from Genheal in this group

Within Weight loss peptides, Genheal also supplies Tirzepatide 20 mg.

What retatrutide did to liver fat

The third receptor, the glucagon receptor, shows most clearly in the liver. A phase 2 study published in 2024 in Nature Medicine looked at 98 people with obesity and fatty liver, without diabetes. Liver fat was measured by magnetic resonance imaging. Less than 5 percent fat in liver tissue counted as a normal result.

Dose studied Fall in fat after 24 weeks Liver without steatosis after 24 weeks Fall in fat after 48 weeks
1 mg 42.9 percent 27 percent of people 51.3 percent
4 mg 57.0 percent 52 percent of people 59.0 percent
8 mg 81.4 percent 79 percent of people 81.7 percent
12 mg 82.4 percent 86 percent of people 86.0 percent
Placebo rise of 0.3 percent 0 percent of people 4.6 percent

After 48 weeks, 93 percent of people on 12 mg and 89 percent on 8 mg had a liver without steatosis. At both doses every participant reduced liver fat by at least 30 percent already after 24 weeks. According to the authors, glucagon increases the burning of fatty acids in liver cells. This is shown by beta-hydroxybutyrate, a marker of that burning, which rose two- to threefold in the blood.

Next to semaglutide and tirzepatide

The authors set their result against earlier studies of other molecules. Tirzepatide reduced liver fat by 47 percent after 52 weeks, and semaglutide by about 50 percent after 72 weeks. Retatrutide at 12 mg gave 82.4 percent already after 24 weeks. These numbers come from different studies and different groups, so they are not a direct comparison.

The liver enzymes ALT and AST gave no signals of liver damage. The group had 98 people, so the result concerns a relatively small sample. All the numbers from this study are gathered in the guide Retatrutide and fatty liver.

Source: Sanyal et al., Nature Medicine 2024.

Questions

How much Retatrutide is in this vial?

20 mg of lyophilised powder from Genheal, in one vial.

What concentration does 2 ml of water give?

10 mg per millilitre, which is 100 mcg per unit on a U-100 insulin syringe. Other volumes are in the table above.

Is this the same molecule as the Bio-Peptide vial?

Yes. Retatrutide is the same compound in every version here, and both vials hold 20 mg. What differs is the manufacturer and the batch certificate that comes with it; the Nouveaux Ltd. pen holds 40 mg as a ready solution.

Verification and delivery

Every vial carries a code under the hologram and comes from a batch with a certificate of analysis; how to check both is described in check your product. We ship within Poland and abroad. Outside Poland shipping costs 30 EUR paid in advance or 80 EUR cash on delivery, the same for every country: shipping and payments.