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Semaglutide, 3 mg. Semaglutide is a GLP-1 receptor agonist, the single-receptor molecule of the incretin group, and in registered form a prescription medicine.

What is in this vial

It is the only Semaglutide vial in this catalogue. The powder has no concentration of its own: it is set when you add the water. This vial with 2 ml of bacteriostatic water gives 1.5 mg per millilitre, and with twice that volume, half as much.

The conversion of an amount into insulin syringe units is worked through in the guide on syringe units, and the rules that change once the powder is dissolved are in storage.

Bio-Peptide as the manufacturer

Bio-Peptide has the widest catalogue of the three brands we stock: it is the only one supplying glutathione, NAD+, GHK-Cu, MOTS-C, SLU-PP-332 and semaglutide, so an order from this manufacturer can usually be filled from one supplier. Every vial carries a code under the hologram and a batch certificate, and how to check both is described on the verification page.

What the evidence says

In obesity trials at 2.4 mg weekly it reduced body weight by roughly 15 percent over about two years. Against tirzepatide in the only head-to-head trial it reached 13.7 percent against 20.2 percent. The full account, with the sources and the limits, is on the Semaglutide page, and the background in the guide on the three incretins compared.

We publish no dosing schedules. Sold as research material, not as a medicine.

Concentration in this vial

Water added Concentration Per unit on a U-100 syringe
1 ml 3 mg/ml 30 mcg
2 ml 1.5 mg/ml 15 mcg
5 ml 0.6 mg/ml 6 mcg

The table is arithmetic and nothing else: it converts the 3 mg in this vial into the concentration you get for a chosen volume of bacteriostatic water. It is not a dosing recommendation, and we publish none.

This vial next to the other Semaglutide vials

No other manufacturer here lists Semaglutide, so this is the only vial of it in the catalogue and there is no brand comparison to make.

Also from Bio-Peptide in this group

Within Weight loss peptides, Bio-Peptide also supplies MOTS-c 10 mg, Retatrutide 20 mg and SLU-PP-332 5 mg.

How the GLP-1 pathway works

GLP-1 is an incretin, a hormone released by the gut in response to a meal. It stimulates insulin release in a glucose-dependent way, slows gastric emptying and acts on the centres of satiety. Semaglutide is an agonist of this receptor: it imitates the natural incretin, only for longer.

The whole family of incretin molecules rests on the same idea. What separates them is the number of receptors they target: semaglutide one, tirzepatide two and retatrutide three. The wider the set of receptors, the higher the average weight reduction in trials and the more side effects reported.

More from the trials

In SURMOUNT-5, the only head-to-head comparison with tirzepatide, waist circumference fell by 13.0 cm with semaglutide and by 18.4 cm with tirzepatide, alongside the weight figures above. One thing counts in favour of semaglutide: it has the longest record of clinical use in this group and the largest body of long-term safety data, which the newer compounds do not yet have.

Medicine and research material

Ozempic and Wegovy This vial
Status Registered prescription medicines Research material
Dose Set and approved Not set
Batch quality control Required by law Not required
Form Ready pen Powder to dissolve
Indications Type 2 diabetes, obesity and overweight with related conditions None, not for use in humans

A research label does not change the legal status of the substance and gives the buyer no guarantee of quality, composition or safety of the kind a registered medicine carries. We say this plainly because in this category the difference is often blurred. The reasons are set out in the guide on why semaglutide and tirzepatide are prescription-only.

Side effects described in trials

Across the incretin group, digestive symptoms dominate: nausea, vomiting, diarrhoea and constipation. In SURMOUNT-5, 5.6 per cent of people in the semaglutide group and 2.7 per cent in the tirzepatide group stopped treatment because of gastrointestinal symptoms. These are data from a clinical trial run under medical supervision.

Who this vial is for

You are interested in the best-studied molecule of the incretin family: this is semaglutide. You want a small amount with fine measuring: 3 mg is one of the smallest vials in our range. You are after a broader action: have a look at tirzepatide or retatrutide. You need treatment: that is a matter for a doctor and a pharmacy. All three are compared in the guide semaglutide, tirzepatide or retatrutide.

Semaglutide and the heart: the SELECT trial

Semaglutide is the active substance of approved drugs, including Ozempic. The numbers below come from a clinical trial of the drug, run under medical supervision. The research material in this vial is not the drug and has neither its label nor its quality control.

SELECT enrolled 17,604 people aged 45 or over with overweight or obesity and previous heart or vascular disease, without diabetes. The trial ran in 41 countries, with a placebo group, for an average of 39.8 months. The results were published in the New England Journal of Medicine in 2023.

Result Semaglutide against placebo
Heart attack, stroke or cardiovascular death 6.5 against 8.0 percent of people, risk 20 percent lower
Death from any cause risk 19 percent lower
People with heart failure risk of heart attack, stroke or cardiovascular death 28 percent lower
CRP after two years 37.8 percent lower
Body weight after 4 years minus 10.2 against minus 1.5 percent

Heart protection did not depend on kilograms

The most interesting result came from a 2025 analysis in The Lancet. Heart protection was similar in people who lost a lot, a little or no weight in the first 20 weeks. The reduction in waist circumference explained about 33 percent of the benefit. The authors conclude that semaglutide acts on the heart through other routes besides fat loss itself.

One of these routes may be inflammation. The fall in CRP was visible already after 4 and 8 weeks, before weight fell clearly, and also appeared in people who did not lose weight. Serious side effects were less frequent on semaglutide than on placebo in every weight group. Dosing in this trial was set by the drug's protocol, and choosing a dose is a matter for a doctor. All the SELECT analyses are described in the guide Semaglutide and the heart.

Sources: Lincoff et al., New England Journal of Medicine 2023, Scirica et al., JACC 2024, Deanfield et al., The Lancet 2025, Deanfield et al., The Lancet 2024, Plutzky et al., Circulation 2026, Ryan et al., Nature Medicine 2024.

Questions

How much Semaglutide is in this vial?

3 mg of lyophilised powder from Bio-Peptide, in one vial.

What concentration does 2 ml of water give?

1.5 mg per millilitre, which is 15 mcg per unit on a U-100 insulin syringe. Other volumes are in the table above.

Is Semaglutide available from another manufacturer here?

No. Bio-Peptide is the only manufacturer of Semaglutide in this catalogue.

Verification and delivery

Every vial carries a code under the hologram and comes from a batch with a certificate of analysis; how to check both is described in check your product. We ship within Poland and abroad. Outside Poland shipping costs 30 EUR paid in advance or 80 EUR cash on delivery, the same for every country: shipping and payments.