HGH Fragment 176-191, 10 mg. HGH Fragment 176-191 is the final sixteen amino acids of the growth hormone molecule, the section linked to fat breakdown, without the parts that bind the growth hormone receptor.
HGH Fragment 176-191 10 mg by Nouveaux Ltd.
55 EUR210,00 złAdd to cart5 in stock (can be backordered)
What is in the pack
It is the largest HGH Fragment 176-191 pack in this catalogue; per milligram it costs slightly more than the 5 mg vials, and it is the one that stands longest in solution once opened. Nouveaux Ltd. supplies this product as a dual-chamber cartridge: 10 mg of freeze-dried powder in one chamber and 1 ml of solvent in the other. The chambers are joined just before first use, so no liquid has to be moved from one container to another. After activation with the included millilitre the solution stands at 10 mg per millilitre, which is 100 mcg per unit on a U-100 syringe.
The conversion of an amount into insulin syringe units is worked through in the guide on syringe units, and the rules that change once the powder is dissolved are in storage.
Nouveaux Ltd. as the manufacturer
Nouveaux Ltd. has the narrowest catalogue of the three and the largest packs: BPC-157 20 mg, CJC-1295 10 mg, sermorelin 10 mg, PEG-MGF 10 mg and follistatin 2 mg are all exclusive to this brand here. A larger pack also stands longer once dissolved, which is the trade-off to weigh before ordering.
What the evidence says
In obese mice, in its modified version AOD9604, it reduced body weight and body fat. In humans AOD9604 missed the main endpoint of a phase 2b trial. The full account, with the sources and the limits, is on the HGH Fragment 176-191 page, and the background in the guide on HGH Fragment 176-191.
We publish no dosing schedules. Sold as research material, not as a medicine.
At 10 mg this is the largest HGH Fragment pack in the catalogue, twice the size the other two brands fill. Set against the stability of the dissolved fragment, that is the trade-off on this page: more substance in one pack against a solution that stands twice as long.
Concentration in this cartridge
| Total liquid | Concentration | Per unit on a U-100 syringe |
|---|---|---|
| 1 ml | 10 mg/ml | 100 mcg |
| 2 ml | 5 mg/ml | 50 mcg |
| 5 ml | 2 mg/ml | 20 mcg |
The table is arithmetic and nothing else: it converts the 10 mg in this cartridge into the concentration for a given total volume of liquid. The 1 ml row is the cartridge as supplied, after the chambers are joined; the other rows show what further dilution would give. It is not a dosing recommendation, and we publish none.
This cartridge next to the HGH Fragment 176-191 vials
The same compound is sold here in two other versions: Bio-Peptide, 5 mg and Genheal, 5 mg. The molecule is identical in each; what differs is the manufacturer and the amount in the pack. This is the largest of the 3 packs and the one that stands longest in solution; per milligram it costs slightly more than the 5 mg vials.
Also from Nouveaux Ltd. in this group
Within Growth hormone peptides, Nouveaux Ltd. also supplies CJC-1295 10 mg, CJC-1295 with DAC 10 mg and GHRP-2 10 mg.
What the fragment is
The full growth hormone molecule has 191 amino acids and is involved in dozens of processes, from bone growth to metabolism. HGH Fragment 176-191 is the final section of that chain, numbered 176 to 191, the region linked to fat breakdown. It lacks the rest of the molecule, including the parts that bind the growth hormone receptor, so it does not raise IGF-1 and does not have the growth and insulin effects of the whole hormone.
That is also why it belongs in the growth hormone group by origin rather than by mechanism. Peptides such as CJC-1295 or ipamorelin make the pituitary release more growth hormone; this fragment does nothing of the kind.
What the studies showed
In obese mice the fragment, in its modified version AOD9604, reduced body weight and body fat. In humans AOD9604 did not bring a significant fall in body weight in a phase 2b trial, and its development was stopped in 2007. The animal result is the one advertising uses; the human result is the one that decided the fate of the molecule. The full account is in the guide on HGH Fragment 176-191.
The cartridge and stability
The Nouveaux Ltd. pack is a dual-chamber cartridge: 10 mg of powder in one chamber and 1 ml of solution in the other, twice the content of the 5 mg vials from the other two brands. The chambers are joined just before first use, so nothing has to be transferred between containers. After activation the solution stands at 10 mg per millilitre, or 100 mcg per unit on a U-100 syringe.
Stability matters here more than usual. The dissolved fragment degrades through deamidation and oxidation, and users report a fall in potency after roughly two weeks in the fridge. A larger pack lasts longer, but once activated it has to be used within that window, so keep it at 2 to 8 degrees Celsius, away from light, and weigh the pack size against how long the solution will stand.
Who this cartridge is for
You want the largest pack of the fragment and nothing to prepare: this is the one. You expect the solution to stand for longer: a 5 mg vial is used up sooner. AOD9604 is on the World Anti-Doping Agency list in category S0, non-approved substances.
The route the fragment takes: the beta-3 receptor in fat tissue
Fragment 176-191 does not bind the growth hormone receptor. So where does its effect on fat come from? The answer came from two 2001 papers on the modified version AOD9604, based on the same section.
| Study | Model | What was found |
|---|---|---|
| Heffernan et al., Endocrinology 2001 | obese mice, 14 days | a fall in body weight and fat tissue, with the beta-3 receptor in fat back to the level of lean mice |
| Same study | mice lacking the beta-3 receptor | the effect on body weight and fat breakdown disappeared |
| Heffernan et al., International Journal of Obesity 2001 | obese mice, 14 days | more fat burned and higher blood glycerol, with no rise in sugar and no fall in insulin secretion |
The beta-3 receptor is a receptor in fat tissue through which the body starts breaking down fat. Obese mice have less of it. The fragment brought it back to the level of lean animals, and without this receptor its effect on body weight disappeared. Blood glycerol is a marker of fat breakdown, so its rise confirms this mechanism.
Why the lack of effect on blood sugar matters
In the same studies, full growth hormone also reduced weight gain, but it raised blood sugar and lowered insulin secretion. The fragment did not. That is exactly the point of using the end section alone: the effect on fat stays, while the effect on sugar metabolism and IGF-1 drops away.
These results come from mouse studies. In humans, AOD9604 missed the main endpoint of its phase 2b trial, and its development was stopped in 2007. This is covered in more detail in the guide HGH Fragment 176-191 and growth hormone.
Sources: Heffernan et al., Endocrinology 2001, Heffernan et al., International Journal of Obesity 2001.
Questions
How much HGH Fragment 176-191 is in this cartridge?
10 mg of lyophilised powder from Nouveaux Ltd., in a dual-chamber cartridge with 1 ml of solvent.
What concentration does the included millilitre give?
10 mg per millilitre, which is 100 mcg per unit on a U-100 insulin syringe. Other volumes are in the table above.
Is this the same molecule as the Bio-Peptide vial?
Yes. HGH Fragment 176-191 is the same compound in every pack here. The difference is the manufacturer and the amount: 10 mg in this one against 5 mg in that one.
Verification and delivery
Every pack carries a code under the hologram and comes from a batch with a certificate of analysis; how to check both is described in check your product. We ship within Poland and abroad. Outside Poland shipping costs 30 EUR paid in advance or 80 EUR cash on delivery, the same for every country: shipping and payments.